Our laboratory routinely analyzes samples that contain biologically active pharmaceuticals such as steroids, peptide hormones, antibody drug conjugates (ADCs) and cytotoxic compounds.
Analytical Methods Employed – The SafeBridge Advantage
The occupational exposure limits and acceptable surface limits specified by the manufacturer are commonly in the range of ng/m3 or below 1 µg/cm2 respectively and, therefore, require highly sensitive analytical methodologies. SafeBridge employs or has access to HPLC, EIA, RIA and LC/MS/MS analytical technologies. Our methods achieve high specificity, ultra sensitivity and high recovery rate through the proper choice of filter media and extracting procedures as well as the optimization of air sampling parameters. The methods are validated with respect to analytical detection limits, precision and accuracy. Data on the stability of compounds relative to airflow volume and storage conditions are contained in these methods. The SafeBridge advantage is that we employ the most sensitive techniques in the industry to detect potent drugs at very low concentrations in the workplace – to quantitation limits as low as 100 picograms/filter.